How might the keto diet help deal with cancer?

    Begum Halsey

    New research in mice suggests that keeping blood glucose under control utilizing either the ketogenic diet or a diabetes drug might assist deal with certain cancers by enhancing the effectiveness of basic chemotherapy.

    The ketogenic diet includes high fat foods, foods that include an adequate quantity of protein, and a very low amount of carbohydrates.

    Generally, the body gets its primary source of energy (sugar) from carbs.

    However, the ketogenic diet deprives the body of glucose, causing a state of "ketosis.".

    During ketosis, the body is forced to break down saved fat rather of sugar to produce an alternative source of energy.

    The ketogenic, or "keto," diet plan has actually been around for centuries. Typically, some have used it as a therapy for conditions such as diabetes and epilepsy.

    More recent studies have actually begun to examine the restorative potential of the keto diet for other conditions, such as cancer, polycystic ovary syndrome, and Alzheimer's disease.

    For example, recent research has actually suggested that the keto diet could complement standard cancer therapies such as chemotherapy and radiation treatment.

    The diet might increase the power of standard cancer treatment by selectively causing metabolic oxidative tension in cancer cells, but not in typical ones.

    Other studies have also suggested that particular cancers are heavily reliant on glucose for energy. So, limiting cancer cells' access to sugar may be a valid method of sensitizing them to chemotherapy.

    Using a mouse design of lung and esophageal cancer, Kim and coworkers limited the rodents' levels of circulating glucose by feeding them a ketogenic diet and administering them a diabetes drug that stops the kidneys from reabsorbing blood sugar level.

    The researchers have actually released their paper in the journal Cell Reports. Meng-Hsiung Hsieh is the very first author.

    Kim and his team have actually previously revealed that a cancer type called squamous cell carcinoma (SCC) relies a lot more on glucose to sustain its "antioxidative capacity and survival" than other kinds of cancer, such as lung adenocarcinoma.

    So, in the new study, the team reasoned that restricting glucose would make SCC more vulnerable to treatment. They fed mice with xenograft growths either a ketogenic diet consisting of 0.1% carbohydrates or a regular chow diet plan.

    " Both the ketogenic diet and the medicinal constraint of blood sugar on their own inhibited the additional development of [SCC] tumors in mice with lung cancer," states Kim.

    " While these interventions did not diminish the growths, they did keep them from progressing, which suggests this kind of cancer may be susceptible to glucose constraint," he adds.

    However, the glucose restriction did not impact other, non-SCC growths. "Our results recommend that this technique is cancer cell type particular. We can not generalize to all kinds of cancer," Kim states.

    The scientists also studied blood glucose levels in samples from 192 people with SCC of the lung or esophagus. They then compared them with those from 120 individuals with lung adenocarcinoma.

    " Surprisingly," states Kim, "we discovered a robust connection between greater blood sugar concentration and even worse survival amongst [people] with [SCC]".

    " We found no such correlation among the lung adenocarcinoma clients. This is a crucial observation that more implicates the potential efficacy of glucose limitation in attenuating [SCC] growth," he includes.